The summary of the presentation is focused on isolated smooth muscle (vascular and non- vascular contractions) using in-vitro organ bath method. Excitable tissues used were from different anatomical sites of the rodents, the gastro-intestinal, Rat stomach strip (RSS) the GIT. The vas deference (VDF), the Reproductive), and the blood vessels (aortic strips ATS). The objectives is to study patterns of contractions in these muscles, using known chemical agents specifically, autonomic drugs) and their interactions on excitation contraction-coupling mechanism under various experimental conditions. The study also explores, in the ATS, the influence of endothelium on blood vessels contractions. Generally, smooth muscles promote physiological contractions i.e. movement in the body and drugs modifies these functions.